SD70 is a potent, selective and cell-permeable inhibitor of histone demethylase JMJD2 (KDM4C), identified by phenotypic screening for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells. Through Chem-seq approach, SD70 was found to inhibit the androgen-dependent AR program and prostate cancer cell growth, acting, at least in part, by functionally inhibiting the Jumonji domain-containing demethylase KDM4C. SD70 inhibits AR target gene expression, inhibits prostate cancer cell growth in vitro and tumor growth in vivo. SD70 holds potential promise for ultimate use in prostate cancer therapy.
CAS Number: 332173-89-4
Molecular Weight: 310.35
Chemical Name: N-(furan-2-yl(8-hydroxyquinolin-7-yl)methyl)isobutyramide
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO up to 50 mM
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
SD70 was used at 10 µM final concentration in various in vitro assays.
SD70 was administered by IP injection at 10 mg/kg once per day in xenografts model.
- Jin C, et al. Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens. (2014) Proc Natl Acad Sci USA. 111(25):9235-40.
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