Manogepix (E1210)

Manogepix (E1210, MGX, APX001A) is a broad-spectrum and orally active antifungal agent that inhibits Gwt1/Gwt1p (GPI-anchored wall transfer protein 1), a protein that plays an important role in fungal cell wall integrity.

Product information

CAS Number: 936339-60-5

Molecular Weight: 358.39

Formula: C21H18N4O2

Synonym:

E-1210

E 1210

APX001A

APX-001-A

APX 001 A

Chemical Name: (3-(3-(4-(((Pyridin-2-yl)oxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-)amine

Smiles: NC1=NC=CC=C1C1=CC(CC2=CC=C(COC3=CC=CC=N3)C=C2)=NO1

InChiKey: WSEKTEUGRLFBSE-UHFFFAOYSA-N

InChi: InChI=1S/C21H18N4O2/c22-21-18(4-3-11-24-21)19-13-17(25-27-19)12-15-6-8-16(9-7-15)14-26-20-5-1-2-10-23-20/h1-11,13H,12,14H2,(H2,22,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 72 mg/mL(200.89 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Olga Rivero-Menendez, et al. J Antimicrob Chemother. 2019 May 1;74(5):1295-1299.

Products are for research use only. Not for human use.