Dihydrosanguinarine

Dihydrosanguinarine is an alkaloid and a metabolite of the alkaloid sanguinarine that has diverse biological activities, including anticancer, fungicidal, and antiprotozoal properties. It inhibits proliferation of PANC-1, SW 1990, and HPDE6c7 cancer cells when used at concentrations of 10, 20, and 30 µM. It also reduces the levels of phosphorylated ERK and C-RAF, halts the cell cycle at the G0/G1 and G2/M phases, and induces apoptosis in PANC-1 cells. Dihydrosanguinarine inhibits spore germination of the phytopathogenic fungi B. cinerea and E. graminis in vitro. It has protective and curative effects against B. cinerea and E. graminis when applied as a spray to plants either before or after infection, respectively, at concentrations of 100 and 500 µg/ml. Dihydrosanguinarine is also effective against I. multifiliis infestation in S. curriculus with an LC50 value of 13.3 mg/L.

Product information

CAS Number: 3606-45-9

Molecular Weight: 333.34

Formula: C20H15NO4

Synonym:

13,14-Dihydrosanguinarine

Chemical Name: 24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.0²,¹⁰.0⁴,⁸.0¹⁴,²².0¹⁷,²¹]tetracosa-1,3,8,10,12,14,16,21-octaene

Smiles: CN1CC2C3OCOC=3C=CC=2C2=CC=C3C=C4OCOC4=CC3=C12

InChiKey: CIUHLXZTZWTVFL-UHFFFAOYSA-N

InChi: InChI=1S/C20H15NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-7H,8-10H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.