HBF-0259

HBF-0259 is a potent and selective inhibitor of hepatitis B virus (HBV) surface antigen (HBsAg) secretion, with an EC50 of 1.5 μM in HepG2.2.15 cells. HBF-0259 has no effect on HBV DNA synthesis.

Product information

CAS Number: 957011-15-3

Molecular Weight: 364.20

Formula: C16H12Cl2FN5

Chemical Name: 7-(2-chloro-6-fluorophenyl)-5-(4-chlorophenyl)-3H,5H,6H,7H-[1,2,3,4]tetrazolo[1,5-a]pyrimidine

Smiles: FC1=CC=CC(Cl)=C1C1CC(N=C2NN=NN21)C1C=CC(Cl)=CC=1

InChiKey: BRBZPYDLUUWBCD-UHFFFAOYSA-N

InChi: InChI=1S/C16H12Cl2FN5/c17-10-6-4-9(5-7-10)13-8-14(24-16(20-13)21-22-23-24)15-11(18)2-1-3-12(15)19/h1-7,13-14H,8H2,(H,20,21,23)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

HBF-0259 (0.0158-50.0 μM) inhibits the HBsAg secretion (EC50=1.5 μM) in HepDE19 cells, with an CC50 of >50 μM. HBF-0259 (2-8 μM) significantly reduces the abundance of both L and M in the supernatants of HepG2.2.15 cells.

Products are for research use only. Not for human use.