INCB13739

INCB13739 is a potent, selective, oral 11βHSD1 inhibitor (IC50=1.1 nM) for the treatment of type 2 diabetes. INCB13739 has high selectivity for 11beta-HSD1 over other dehydrogenases and glucocorticoid and mineralocorticoid receptors, with prolonged pharmacodynamic activity and good pharmacokinetic/pharmacodynamic properties. INCB13739 demonstrated improved hepatic and peripheral insulin sensitivity with a satisfactory reduction in fasting plasma glucose and cholesterol.

Product information

CAS Number: 872506-67-7

Molecular Weight: 398.95

Formula: C19H27ClN2O3S

Synonym:

INCB-13739

CID 11502183

Chemical Name: (3S)-1-(3-chloro-2-methylbenzenesulfonyl)-N-cyclohexylpiperidine-3-carboxamide

Smiles: CC1C(=CC=CC=1Cl)S(=O)(=O)N1CCC[C@@H](C1)C(=O)NC1CCCCC1

InChiKey: ODRPEKCTTLECBX-HNNXBMFYSA-N

InChi: InChI=1S/C19H27ClN2O3S/c1-14-17(20)10-5-11-18(14)26(24,25)22-12-6-7-15(13-22)19(23)21-16-8-3-2-4-9-16/h5,10-11,15-16H,2-4,6-9,12-13H2,1H3,(H,21,23)/t15-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: This drug may be formulated in DMSO

HS Tariff Code: 382200

Products are for research use only. Not for human use.