Description
TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with Ki of 5.3 nM for human PHD2. TP0463518 inhibits human PHD1, human PHD3 and monkey PHD2 with IC50 of 18 nM, 63 nM and 22 nM, respectively.
Product information
CAS Number: 1558021-37-6
Molecular Weight: 431.83
Formula: C20H18ClN3O6
Chemical Name: (1-((6-(4-chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1, 2, 5, 6-tetrahydropyridine-3-carbonyl)glycine
Smiles: OC(=O)CNC(=O)C1C(=O)N(CC2C=NC(=CC=2)OC2C=CC(Cl)=CC=2)CCC=1O
InChiKey: HMMHKGLPKAQOOH-UHFFFAOYSA-N
InChi: InChI=1S/C20H18ClN3O6/c21-13-2-4-14(5-3-13)30-16-6-1-12(9-22-16)11-24-8-7-15(25)18(20(24)29)19(28)23-10-17(26)27/h1-6,9,25H,7-8,10-11H2,(H,23,28)(H,26,27)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO 40 mg/mL (92.63 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Sota Kato, et al. Eur J Pharmacol. 2018 Nov 5;838:138-144.
Products are for research use only. Not for human use.
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