Desidustat

Desidustat (ZYAN1, ZYAN1-1001), an antianaemic drug candidate, is an orally active hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor (HIF-PHI) that stimulates erythropoiesis.

Product information

CAS Number: 1616690-16-4

Molecular Weight: 332.31

Formula: C16H16N2O6

Synonym:

ZYAN1

ZYAN1-1001

Chemical Name: N-[1-(cyclopropylmethoxy)-4-hydroxy-2-oxo- 1,2-dihydroquinoline-3-carbonyl]glycine

Smiles: OC(=O)CNC(=O)C1C(=O)N(OCC2CC2)C2=CC=CC=C2C=1O

InChiKey: IKRKQQLJYBAPQT-UHFFFAOYSA-N

InChi: InChI=1S/C16H16N2O6/c19-12(20)7-17-15(22)13-14(21)10-3-1-2-4-11(10)18(16(13)23)24-8-9-5-6-9/h1-4,9,21H,5-8H2,(H,17,22)(H,19,20)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 10 mg/mL (30.09 mM) Ethanol 2 mg/mL (6.02 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

In BALB/c mice, a single dose treatment of desidustat attenuates the effect of lipopolysaccharide (LPS) - or turpentine oil-induced inflammation and increased serum erythropoietin (EPO), iron, and reticulocyte count, and decreases serum hepcidin levels. In turpentine oil-induced anemia in BALB/c mice, repeated dose desidustat treatment increases hemoglobin, RBC and hematocrit in a dose related manner. In female Lewis rats, treatment with desidustat markedly reduces PGPS-induced anemia and increases hemoglobin, red blood cell (RBC) and white blood cell (WBC) count, hematocrit, serum iron and spleen iron.

References:

1. Deven V Parmar, et al. Am J Nephrol. 2019;49(6):470-478.
2. Mukul Jain, et al. Eur J Pharmacol. 2019 Jan 15;843:113-120.

Products are for research use only. Not for human use.