(S)-HH2853

(S)-HH2853 (compound 200), a PYRIDINO five membered aromatic ring compound, is a potent EZH1/2 dual inhibitor with an IC50 of <100 nM for EZH2_Y641F. (S)-HH2853 has the potential to be used in the research of anti-tumor or autoimmune diseases.

Product information

CAS Number: 2202678-05-3

Molecular Weight: 611.66

Formula: C31H36F3N7O3

Smiles: CC1=CC=C(N=N1)C1C=CN2C([C@H](C)N3CCN(CC(F)(F)F)CC3)=C(C)C(=CC2=1)C(=O)NCC1=C(C=C(C)NC1=O)OC

InChiKey: BIABSPVTTUDBEO-NRFANRHFSA-N

InChi: InChI=1S/C31H36F3N7O3/c1-18-6-7-25(38-37-18)22-8-9-41-26(22)15-23(29(42)35-16-24-27(44-5)14-19(2)36-30(24)43)20(3)28(41)21(4)40-12-10-39(11-13-40)17-31(32,33)34/h6-9,14-15,21H,10-13,16-17H2,1-5H3,(H,35,42)(H,36,43)/t21-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Xuxing Chen, et al. PYRIDINO five membered aromatic ring compounds, preparation method and application thereof. WO2018045971A1.

Products are for research use only. Not for human use.