NBI-31772 hydrate


Catalog No. Size PriceQuantity
M15240-2 Contact sales@xcessbio.com for quotation $100

Description

NBI-31772 hydrate is a potent inhibitor of interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). NBI-31772 hydrate is also a nonpeptide ligand that releases bioactive IGF-I from the IGF-I/IGFBP-3 complex (Kis=1-24 nM for all six human subtypes). Anxiolytic and antidepressant-like effects.

Product information

Molecular Weight: 372.80

Formula: C68H58N4O35

Chemical Name: tetrakis(1-(3,4-dihydroxybenzoyl)-6,7-dihydroxyisoquinoline-3-carboxylic acid) heptahydrate

Smiles: O.O.O.O.O.O.O.OC(=O)C1=CC2=CC(O)=C(O)C=C2C(=N1)C(=O)C1=CC(O)=C(O)C=C1.OC(=O)C1=CC2=CC(O)=C(O)C=C2C(=N1)C(=O)C1=CC(O)=C(O)C=C1.OC(=O)C1=CC2=CC(O)=C(O)C=C2C(=N1)C(=O)C1=CC(O)=C(O)C=C1.OC(=O)C1=CC2=CC(O)=C(O)C=C2C(=N1)C(=O)C1=CC(O)=C(O)C=C1

InChiKey: VPUOQTDTRRNXBR-UHFFFAOYSA-N

InChi: InChI=1S/4C17H11NO7.7H2O/c4*19-11-2-1-7(4-12(11)20)16(23)15-9-6-14(22)13(21)5-8(9)3-10(18-15)17(24)25;;;;;;;/h4*1-6,19-22H,(H,24,25);7*1H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

NBI-31772 (5-100 μg; icv; immediately or at 1, 2, or, 3 hours after MCAO) at the time of ischemia onset also dose-dependently reduced infarct size, and the highest dose (100 μg) significantly reduced both total and cortical infarct volume.

Products are for research use only. Not for human use.

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