Description
Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).
Product information
CAS Number: 835616-60-9
Molecular Weight: 276.22
Formula: C13H9FN2O4
Synonym:
Cereblon ligand 4
E3 ligase Ligand 4
Chemical Name: 2-(2, 6-dioxopiperidin-3-yl)-4-fluoro-2, 3-dihydro-1H-isoindole-1, 3-dione
Smiles: O=C1CCC(C(=O)N1)N1C(=O)C2=C(F)C=CC=C2C1=O
InChiKey: CRAUTELYXAAAPW-UHFFFAOYSA-N
InChi: InChI=1S/C13H9FN2O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5H2,(H,15,17,18)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 200 mg/mL (724.06 mM; Need ultrasonic and warming)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.
Products are for research use only. Not for human use.
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