Description
MDK6664, also known as LPA2-IN-1 or LPA2 antagonist 1, is a potent LPA2 antagonist with IC50 17 nM in vitro for inhibition of LPA(2) mediated Erk activation and proliferation of HCT-116 cells. Lysophosphatidic acid (LPA) acts via binding to specific G protein-coupled receptors and has been implicated in the biology of breast cancer.
Product information
CAS Number: 1017606-66-4
Molecular Weight: 500.46
Formula: C20H23Cl2N5O2S2
Chemical Name: N-[(2S)-1-[4-(3,4-dichlorobenzenesulfonyl)piperazin-1-yl]propan-2-yl]-7-methylthieno[3,2-d]pyrimidin-4-amine
Smiles: CC1=CSC2=C1N=CN=C2N[C@@H](C)CN1CCN(CC1)S(=O)(=O)C1=CC(Cl)=C(Cl)C=C1
InChiKey: BPRNMVDTWIHULJ-AWEZNQCLSA-N
InChi: InChI=1S/C20H23Cl2N5O2S2/c1-13-11-30-19-18(13)23-12-24-20(19)25-14(2)10-26-5-7-27(8-6-26)31(28,29)15-3-4-16(21)17(22)9-15/h3-4,9,11-12,14H,5-8,10H2,1-2H3,(H,23,24,25)/t14-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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