Description
Zaleplon is a sedative-hypnotic, almost entirely used for the management/treatment of insomnia. Zaleplon is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class. Zaleplon, like zolpidem, zopiclone, or eszopiclone, are all specific agonists at the benzodiazepine GABAA α1 sub-receptor site. It also modulates the GABAA sub-sites, α2 and α3, to a lesser degree. It has no statistical significance as an anticonvulsant. However, as a pyrazolopyrimidine, zaleplon has served as a novel chemical platform from which new anxiolytics will hopefully arise. Much like zolpidem, as an imidazopyridine and also a full agonist at the GABAA α1 sub-receptor site, has been reviewed considerably with some novel contributions.
Product information
CAS Number: 151319-34-5
Molecular Weight: 305.33
Formula: C17H15N5O
Chemical Name: N-[3-(3-cyanopyrazolo[1, 5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide
Smiles: CC(=O)N(CC)C1=CC(=CC=C1)C1=CC=NC2=C(C=NN12)C#N
InChiKey: HUNXMJYCHXQEGX-UHFFFAOYSA-N
InChi: InChI=1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO, not in water
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Stranks EK, Crowe SF. The acute cognitive effects of zopiclone, zolpidem, zaleplon, and eszopiclone: a systematic review and meta-analysis. J Clin Exp Neuropsychol. 2014;36(7):691-700.
- Weitzel KW, Wickman JM, Augustin SG, Strom JG. Zaleplon: a pyrazolopyrimidine sedative-hypnotic agent for the treatment of insomnia. Clin Ther. 2000 Nov;22(11):1254-67.
Products are for research use only. Not for human use.
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