Matrine

Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and u-receptor agonist.

Product information

CAS Number: 519-02-8

Molecular Weight: 248.36

Formula: C15H24N2O

Synonym:

Matridin-15-one

NSC 146051

NSC146051

NSC-146051

Chemical Name: (1R, 2R, 9S, 17S)-7, 13-diazatetracyclo[7.7.1.0, .0, ]heptadecan-6-one

Smiles: O=C1CCC[C@@H]2[C@H]3CCCN4CCC[C@@H](CN12)[C@H]43

InChiKey: ZSBXGIUJOOQZMP-JLNYLFASSA-N

InChi: InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 49 mg/mL(197.29 mM). Water: 11 mg/mLwarmed(44.29 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. Matrine significantly inhibites the growth of human non-small cell lung cancer A549 and hepatoma SMMC-7721 cells and induces apoptosis by strongly reducing the viability and the ratio of Bcl-2/Bax protein in A549 cells. matrine may stimulate the descending dynorphinergic neuron, resulting in the stimulation of kappa-opioid receptors (KORs) in the spinal cord, and this phenomenon in turn produces the antinociception in mice.

In Vivo:

LD50: Mice 157mg/kg (i.p.)

References:

1. Wang XY, et al. Nanfang Yike Daxue Xuebao, 2010, 30(9), 2154-2155.
2. Higashiyama K, et al. Biol Pharm Bull, 2005, 28(5), 845-848.
3. Zhang Y, et al. Cytotechnology, 2009, 59(3), 191-200.

Products are for research use only. Not for human use.