CNT2 inhibitor-1

CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2.

Product information

CAS Number: 880155-70-4

Molecular Weight: 448.47

Formula: C23H24N6O4

Chemical Name: (2R,3R,4S,5R)-2-{6-amino-8-[({[1,1'-biphenyl]-4-yl}methyl)amino]-9H-purin-9-yl}-5-(hydroxymethyl)oxolane-3,4-diol

Smiles: NC1=NC=NC2=C1N=C(NCC1C=CC(=CC=1)C1C=CC=CC=1)N2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

InChiKey: YJLIKUSWRSEPSM-WGQQHEPDSA-N

InChi: InChI=1S/C23H24N6O4/c24-20-17-21(27-12-26-20)29(22-19(32)18(31)16(11-30)33-22)23(28-17)25-10-13-6-8-15(9-7-13)14-4-2-1-3-5-14/h1-9,12,16,18-19,22,30-32H,10-11H2,(H,25,28)(H2,24,26,27)/t16-,18-,19-,22-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 75 mg/mL (167.24 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CNT2 inhibitor-1 (compound 48) exhibits 81-fold more potent inhibitory activity than the parent compound 12. In addition, CNT2 inhibitor-1 exhibits inhibitory activity 1500-fold more potent than that of 2’-deoxy-5-fluorouridine, phlorizin, and 7,8,3’-trihydroxyflavone, which are well-known hCNT2 inhibitors. CNT2 inhibitor-1 (compound 1) is a potent inhibitor with poor solubility.

References:

1. Tatani K, et al. Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors. ACS Med Chem Lett. 2015 Jan 28;6(3):244-8.

Products are for research use only. Not for human use.