Description
L 012 sodium salt a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2•−) and identify Nox inhibitors.
Product information
CAS Number: 143556-24-5
Molecular Weight: 310.67
Formula: C13H8ClN4NaO2
Chemical Name: sodium 8-amino-5-chloro-4-oxo-7-phenyl-3, 4-dihydropyrido[3, 4-d]pyridazin-1-olate
Smiles: [Na+].NC1=C(N=C(Cl)C2C(=O)NN=C([O-])C=21)C1C=CC=CC=1
InChiKey: IGEUYSJHQQCEFP-UHFFFAOYSA-M
InChi: InChI=1S/C13H9ClN4O2.Na/c14-11-8-7(12(19)17-18-13(8)20)9(15)10(16-11)6-4-2-1-3-5-6;/h1-5H,15H2,(H,17,19)(H,18,20);/q;+1/p-1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 50 mg/mL (160.94 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
L-012 sodium salt, a chemical analog of luminol, gives rise to significantly higher luminescence yield and increased sensitivity as compared to other CL probes, lucigenin and MCLA.
In Vivo:
L-012 sodium salt is well distributed in the mouse body and mediates a strong ROS/RNS-dependent luminescent signal in vivo and is useful for monitoring the development and regulation of inflammation in living organisms.
Products are for research use only. Not for human use.
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