ML359 - CAS# 1069858-99-6


Catalog No. Size PriceQuantity
M16651-C Contact sales@xcessbio.com for quotation $100

Description

ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC50 of 250 nM. ML359 can prevent thrombus formation in vivo.

Product information

CAS Number: 1069858-99-6

Molecular Weight: 350.37

Formula: C19H18N4O3

Chemical Name: N-ethyl-N-{7-methoxy-1-methyl-1H-pyrazolo[3,4-b]quinolin-3-yl}furan-2-carboxamide

Smiles: CN1N=C(C2=CC3=CC=C(C=C3N=C12)OC)N(CC)C(=O)C1=CC=CO1

InChiKey: GKJQVQCIPPIODP-UHFFFAOYSA-N

InChi: InChI=1S/C19H18N4O3/c1-4-23(19(24)16-6-5-9-26-16)18-14-10-12-7-8-13(25-3)11-15(12)20-17(14)22(2)21-18/h5-11H,4H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (239.27 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ML359 是一种有效,选择性和可逆的蛋白质二硫键异构酶 (PDI) 抑制剂,IC50 值为 250 nM。ML359 可以抑制体内血栓形成。

In Vivo:

ML359 inhibits of thrombus formation in a mouse laser injury model.

Products are for research use only. Not for human use.

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