GGTI-2154 hydrochloride - CAS# 478908-50-8


Catalog No. Size PriceQuantity
M16717-C Contact sales@xcessbio.com for quotation $100

Description

GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can be used for the research of cancer.

Product information

CAS Number: 478908-50-8

Molecular Weight: 456.97

Formula: C24H29ClN4O3

Chemical Name: (5-(((1H-imidazol-4-yl)methyl)amino)-2'-methyl-[1, 1'-biphenyl]-2-carbonyl)-L-leucine hydrochloride

Smiles: Cl.CC1=CC=CC=C1C1=CC(=CC=C1C(=O)N[C@@H](CC(C)C)C(O)=O)NCC1=CNC=N1

InChiKey: JQRKKNPKMYXQRS-FTBISJDPSA-N

InChi: InChI=1S/C24H28N4O3.ClH/c1-15(2)10-22(24(30)31)28-23(29)20-9-8-17(26-13-18-12-25-14-27-18)11-21(20)19-7-5-4-6-16(19)3;/h4-9,11-12,14-15,22,26H,10,13H2,1-3H3,(H,25,27)(H,28,29)(H,30,31);1H/t22-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (547.08 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

GGTI-2154 inhibits the transfer of geranylgeranyl from [3H]GGPP to H-Ras CVLL, with an IC50 of 21 nM.

In Vivo:

GGTI-2154 (100 mg/kg/day; s.c. for 14 days) induces breast tumor regression in MMTV-ν-Ha-Ras transgenic mice. GGTI-2154 (50 mg/kg/day; i.p. for 50 day) inhibits A-549 tumor growth in nude mice by 60%.

Products are for research use only. Not for human use.

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