Description
RNF5 inhibitor inh-02 is a potent inhibitor of E3 ubiquitin ligase RNF5/RMA1. RNF5 inhibitor inh-02 leads to significant F508del-CFTR rescue (EC50=2.2 uM) in bronchial epithelial cells homozygous for the F508del mutation. RNF5 inhibitor inh-02 can be used for cystic fibrosis research.
Product information
CAS Number: 324579-65-9
Molecular Weight: 384.50
Formula: C23H20N4S
Chemical Name: N-(4-benzyl-3-methyl-4,5-dihydro-1,2,4-thiadiazol-5-ylidene)-N'-phenylbenzenecarboximidamide
Smiles: CC1=NSC(=NC(=NC2C=CC=CC=2)C2C=CC=CC=2)N1CC1C=CC=CC=1
InChiKey: FYZFQLYZABRFAZ-KUXGFVDGSA-N
InChi: InChI=1S/C23H20N4S/c1-18-26-28-23(27(18)17-19-11-5-2-6-12-19)25-22(20-13-7-3-8-14-20)24-21-15-9-4-10-16-21/h2-16H,17H2,1H3/b24-22+,25-23-
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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