A 438079 Hydrochloride


Catalog No. Size PriceQuantity
M10017-2 Solid 2 mg $95
M10017-10 Solid 10 mg $285

Description

A-438079 is a P2X7 receptor antagonist. A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. P2X7R inhibitor A-438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure-induced neuronal death in the neocortex. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson's disease.

Product information

CAS Number: 899431-18-6

Molecular Weight: 342.61

Formula: C13H10Cl3N5

Chemical Name: 3-{[5-(2,3-dichlorophenyl)-1H-1,2,3,4-tetrazol-1-yl]methyl}pyridine hydrochloride

Smiles: Cl.ClC1=CC=CC(C2=NN=NN2CC2=CN=CC=C2)=C1Cl

InChiKey: MBTJFFMIPPMRGR-UHFFFAOYSA-N

InChi: InChI=1S/C13H9Cl2N5.ClH/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9;/h1-7H,8H2;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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