FR 167653


Catalog No. Size PriceQuantity
M12287-2 Contact sales@xcessbio.com for quotation $100
M12287-10 Contact sales@xcessbio.com for quotation $100

Description

FR 167653 (FR 167653 sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo.

Product information

CAS Number: 158876-66-5

Molecular Weight: 525.51

Formula: C24H20FN5O6S

Synonym:

FR 167653 sulfate

Chemical Name: 1-[7-(4-fluorophenyl)-8-(pyridin-4-yl)-1H, 2H, 3H, 4H-pyrazolo[3, 2-c][1, 2, 4]triazin-2-yl]-2-phenylethane-1, 2-dione; sulfuric acid

Smiles: OS(O)(=O)=O.O=C(C(=O)C1C=CC=CC=1)N1CCN2N=C(C(=C2N1)C1C=CN=CC=1)C1C=CC(F)=CC=1

InChiKey: KCPHXRBKBLJJJJ-UHFFFAOYSA-N

InChi: InChI=1S/C24H18FN5O2.H2O4S/c25-19-8-6-17(7-9-19)21-20(16-10-12-26-13-11-16)23-28-30(15-14-29(23)27-21)24(32)22(31)18-4-2-1-3-5-18;1-5(2,3)4/h1-13,28H,14-15H2;(H2,1,2,3,4)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

FR 167653 (FR 167653 sulfate) (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis.

References:

  1. Furuichi K, et al. Administration of FR167653, a new anti-inflammatory compound, prevents renal ischaemia/reperfusion injury in mice. Nephrol Dial Transplant. 2002 Mar;17(3):399-407.
  2. Iwata Y, et al. p38 Mitogen-activated protein kinase contributes to autoimmune renal injury in MRL-Fas lpr mice. J Am Soc Nephrol. 2003 Jan;14(1):57-67.
  3. Kawashima Y, et al. FR167653 attenuates ischemia and reperfusion injury of the rat lung with suppressing p38mitogen-activated protein kinase. J Heart Lung Transplant. 2001 May;20(5):568-74.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed