MJ33-OH lithium


Catalog No. Size PriceQuantity
M30169-C Contact sales@xcessbio.com for quotation $100

Description

MJ33-OH lithium is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6.

Product information

CAS Number: 1135306-36-3

Molecular Weight: 514.48

Formula: C22H43F3LiO7P

Chemical Name: lithium(1+) {[1-(hexadecyloxy)-3-(2,2,2-trifluoroethoxy)propan-2-yl phosphonato]oxy}methanol

Smiles: [Li+].CCCCCCCCCCCCCCCCOCC(COCC(F)(F)F)OP([O-])(=O)OCO

InChiKey: MSNFEQOPGDWXDX-UHFFFAOYSA-M

InChi: InChI=1S/C22H44F3O7P.Li/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-29-17-21(18-30-19-22(23,24)25)32-33(27,28)31-20-26;/h21,26H,2-20H2,1H3,(H,27,28);/q;+1/p-1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

MJ33 (0.5 μM/kg; by tail vein, at 24 h before MCAO) significantly blocks the increase IL-1β, IL-17 and IL-23 in rats stimulated by Prdx6 siRNA treatment. Compared with the Prdx6 siRNA group, combined exposure to Prdx6 siRNA and MJ33 significantly downregulates the mRNA and protein expression of NF-κB, iNOS and COX-2.

Products are for research use only. Not for human use.

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