CAL-101

Idelalisib, also known as CAL-101, is a PI3K-delta inhibitor with potential immunomodulating and antineoplastic activities. CAL-101 inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. CAL-101 has [EC(50)] = 8nM.

Product information

CAS Number: 870281-82-6

Molecular Weight: 415.42

Formula: C22H18FN7O

Synonym:

CAL101

GS-1101

GS1101

GS 1101

CAL 101

Idelalisib

Chemical Name: 5-fluoro-3-phenyl-2-[(1S)-1-[(7H-purin-6-yl)amino]propyl]-3,4-dihydroquinazolin-4-one

Smiles: CC[C@H](NC1=NC=NC2N=CNC=21)C1=NC2=CC=CC(F)=C2C(=O)N1C1C=CC=CC=1

InChiKey: IFSDAJWBUCMOAH-HNNXBMFYSA-N

InChi: InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.