KT5720

KT5720 is a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (PKA), with a Ki of 60 nM.

Product information

CAS Number: 108068-98-0

Molecular Weight: 537.61

Formula: C32H31N3O5

Chemical Name: hexyl (15R, 16S, 18S)-16-hydroxy-15-methyl-3-oxo-28-oxa-4, 14, 19-triazaoctacyclo[12.11.2.1, .0, .0, .0, .0, .0, ]octacosa-1(26), 2(6), 7(27), 8, 10, 12, 20(25), 21, 23-nonaene-16-carboxylate

Smiles: C[C@@]12O[C@@H](C[C@@]1(O)C(=O)OCCCCCC)N1C3C4=C(C5=CC=CC=C5N24)C2CNC(=O)C=2C=3C2C=CC=CC1=2

InChiKey: ZHEHVZXPFVXKEY-RUAOOFDTSA-N

InChi: InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Methanol : 5 mg/mL (9.30 mM; Need ultrasonic and warming)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
2. Murray A, et al. Pharmacological PKA inhibition: all may not be what it seems. Sci Signal. 2008 Jun 3;1(22):re4.

Products are for research use only. Not for human use.