Bisindolylmaleimide IV

Bisindolylmaleimide IV is an inhibitor of pyruvate phosphate dikinase (PPDK).

Product information

CAS Number: 119139-23-0

Molecular Weight: 327.34

Formula: C20H13N3O2

Chemical Name: 3,4-Bis(1H-indol-3-yl)pyrrole-2,5-dione

Smiles: O=C1NC(=O)C(=C1C1=CNC2=CC=CC=C21)C1=CNC2=CC=CC=C21

InChiKey: DQYBRTASHMYDJG-UHFFFAOYSA-N

InChi: InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

Bisindolylmaleimide IV (Arcyriarubin A) inhibits PKC with an IC50 of 0.1 μM in 1 % DMSO, while the IC50 of 0.55 μM in 10 % DMSO.

References:

1. Minges A, Groth G. Small-molecule inhibition of pyruvate phosphate dikinase targeting the nucleotide binding site. PLoS One. 2017 Jul 10;12(7):e0181139. doi: 10.1371/journal.pone.0181139. eCollection 2017. PubMed PMID: 28700696; PubMed Central PMCID: PMC5507339.

Products are for research use only. Not for human use.