Description
TCO-PEG4-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Product information
CAS Number: 2243569-23-3
Molecular Weight: 540.69
Formula: C28H48N2O8
Chemical Name: (4Z)-cyclooct-4-en-1-yl N-[14-({[(4Z)-cyclooct-4-en-1-yloxy]carbonyl}amino)-3,6,9,12-tetraoxatetradecan-1-yl]carbamate
Smiles: O=C(NCCOCCOCCOCCOCCNC(=O)OC1CCC=CCCC1)OC1CCC=CCCC1 |c:24,34|
InChiKey: ZLDVUVLAIKSQGP-LEWNYYKSSA-N
InChi: InChI=1S/C28H48N2O8/c31-27(37-25-11-7-3-1-4-8-12-25)29-15-17-33-19-21-35-23-24-36-22-20-34-18-16-30-28(32)38-26-13-9-5-2-6-10-14-26/h1-3,5,25-26H,4,6-24H2,(H,29,31)(H,30,32)/b3-1-,5-2-
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
- Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.
Products are for research use only. Not for human use.
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