Description
TCO-PEG6-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Product information
CAS Number: 2353409-94-4
Molecular Weight: 476.60
Formula: C23H44N2O8
Chemical Name: (4Z)-cyclooct-4-en-1-yl N-(20-amino-3,6,9,12,15,18-hexaoxaicosan-1-yl)carbamate
Smiles: NCCOCCOCCOCCOCCOCCOCCNC(=O)OC1CCCC=CCC1 |c:29|
InChiKey: UWVQQISAJNIKQB-UPHRSURJSA-N
InChi: InChI=1S/C23H44N2O8/c24-8-10-27-12-14-29-16-18-31-20-21-32-19-17-30-15-13-28-11-9-25-23(26)33-22-6-4-2-1-3-5-7-22/h1-2,22H,3-21,24H2,(H,25,26)/b2-1-
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References:
- Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.
Products are for research use only. Not for human use.
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