Description
RAMB4, CAS No. 145888-79-5, also known as PTP1B-IN-9, is a ubiquitin-proteasome system (UPS)-stressor. RAMB4 selectively reduces the viability of cervical cancer cells independently of HPV genotype via blockade of proteasomal degradation. RAMB4 treatment triggers a Ubiquitin-Proteasome-System (UPS)-stress response without affecting 20S proteasome catalytic activities.
Product information
CAS Number: 145888-79-5
Molecular Weight: 413.12
Formula: C19H13Cl4NO
Synonym:
PTP1B-IN 9
PTP1B-IN9
RAMB4
RAMB 4
PTP1B-IN-9
RAMB-4
Chemical Name: (3E,5E)-3,5-Bis(3,4-dichlorobenzylidene)piperidin-4-one
Smiles: O=C1/C(/CNC/C/1=C\C1=CC(Cl)=C(Cl)C=C1)=C/C1=CC(Cl)=C(Cl)C=C1
InChiKey: GJPXGFGIFQWUOC-ACFHMISVSA-N
InChi: InChI=1S/C19H13Cl4NO/c20-15-3-1-11(7-17(15)22)5-13-9-24-10-14(19(13)25)6-12-2-4-16(21)18(23)8-12/h1-8,24H,9-10H2/b13-5+,14-6+
Technical Data
Appearance: Solid Power.
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined.
HS Tariff Code: 382200
How to use
In Vitro:
PTP1B-IN-9 (0-30 µM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively. PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 µM.
References:
- Anchoori RK, et al. Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.PLoS One. 2011;6(8):e23888.
Products are for research use only. Not for human use.
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