MRTX1133


Catalog No. Size PriceQuantity
M33399-2 2 mg solid $985
M33399-10 10 mg solid $3,200
M33399-C Contact sales@xcessbio.com for quotation $100

Description

MRTX1133 is a potent and selective KRAS G12D inhibitor. MRTX1133 targets the KRAS G12D protein in both active and inactive states. In preclinical studies, MRTX1133 exhibited a long half-life, an ability to bind the KRAS G12D protein in both active and inactive states, and selective inhibition of KRAS G12D mutant cancer cells. In G12D mutant tumor models, MRTX1133 showed dose-dependent selective inhibition of the KRAS pathway and tumor regression.

Product information

CAS Number: 2621928-55-8

Molecular Weight: 600.63

Formula: C33H31F3N6O2

Chemical Name: 2-Naphthalenol

Smiles: C#CC1=C2C(=CC(O)=CC2=CC=C1F)C1=NC=C2C(=NC(=NC2=C1F)OC[C@]12C[C@@H](F)CN1CCC2)N1CC2CCC(C1)N2

InChiKey: SCLLZBIBSFTLIN-IFMUVJFISA-N

InChi: InChI=1S/C33H31F3N6O2/c1-2-23-26(35)7-4-18-10-22(43)11-24(27(18)23)29-28(36)30-25(13-37-29)31(41-15-20-5-6-21(16-41)38-20)40-32(39-30)44-17-33-8-3-9-42(33)14-19(34)12-33/h1,4,7,10-11,13,19-21,38,43H,3,5-6,8-9,12,14-17H2/t19-,20?,21?,33+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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