Octahydrocurcumin

Octahydrocurcumin is an active metabolite of curcumin that has diverse biological activities. It scavenges DPPH radicals in a cell-free assay (IC50 = 12.3 µM). Octahydrocurcumin (6.25 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 levels, production of nitric oxide (NO), and nuclear translocation of NF-ᴋB in RAW 264.7 cells. It is active against the bacteria B. subtilis, K. pneumoniae, E. coli, E. aerogenes, P. aeruginosa, and S. aureus, as well as C. albicans and the plant pathogenic fungus A. niger, in disc assays. Octahydrocurcumin (5, 10, and 20 mg/kg) increases survival, reduces tumor weight, and induces tumor cell apoptosis in an H22 murine hepatocellular carcinoma model.

Product information

CAS Number: 36062-07-4

Molecular Weight: 376.44

Formula: C21H28O6

Synonym:

Hexahydrobisdemethoxycurcumin

Chemical Name: 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-diol

Smiles: COC1C=C(CCC(O)CC(O)CCC2C=C(OC)C(O)=CC=2)C=CC=1O

InChiKey: OELMAFBLFOKZJD-UHFFFAOYSA-N

InChi: InChI=1S/C21H28O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,16-17,22-25H,3-4,7-8,13H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.