VTP-27999 TFA, a renin inhibitor


Catalog No. Size PriceQuantity
M10847-2 Solid 2 mg $125
M10847-10 Solid 10 mg $375

Description

VTP-27999 is a highly potent and selective renin inhibitor (IC50 = 0.47 nM). VTP-27999 demonstrated excellent selectivity over related and unrelated off-targets, >15% oral bioavailability in three species, oral efficacy in a double transgenic rat model of hypertension, and good exposure in humans.

Product information

CAS Number: 1013937-63-7

Molecular Weight: 639.10

Formula: C28H42ClF3N4O7

Synonym:

VTP 27999, 2,2,2-trifluoroacetate

VTP27999, 2,2,2-trifluoroacetate

Chemical Name: methyl N-{2-[(R)-(3-chlorophenyl)[(3R)-1-{[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]carbamoyl}piperidin-3-yl]methoxy]ethyl}carbamate; trifluoroacetic acid

Smiles: COC(=O)NCCO[C@H]([C@@H]1CCCN(C1)C(=O)NC[C@H](C[C@H]1CCCOC1)NC)C1=CC(Cl)=CC=C1.OC(=O)C(F)(F)F

InChiKey: SYWYSVAEGXHOJO-VIEYARBJSA-N

InChi: InChI=1S/C26H41ClN4O5.C2HF3O2/c1-28-23(14-19-6-5-12-35-18-19)16-30-25(32)31-11-4-8-21(17-31)24(20-7-3-9-22(27)15-20)36-13-10-29-26(33)34-2;3-2(4,5)1(6)7/h3,7,9,15,19,21,23-24,28H,4-6,8,10-14,16-18H2,1-2H3,(H,29,33)(H,30,32);(H,6,7)/t19-,21-,23+,24+;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Solubility (25°C) DMSO: 100 mg/mL(156.47 mM). Water: 100 mg/mL(156.47 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Jia L, et al. ACS Med Chem Lett. 2011 Aug 9;2(10):747-51.

Products are for research use only. Not for human use.

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