Necrostatin-1


Catalog No. Size PriceQuantity
M9540-2 Solid 2 mg $80
M9540-10 Solid 10 mg $240

Description

Necrostatin-1 is a potent and selective inhibitor of necroptosis, a mechanism of programmed cell death separate from apoptosis. Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade. Necrostatin-1 inhibits RIP1 kinase the key upstream kinase involved in the activation of necroptosis (EC50=180nM).

Product information

CAS Number: 4311-88-0

Molecular Weight: 259.33

Formula: C13H13N3OS

Chemical Name: 5-[(1H-indol-3-yl)methyl]-3-methyl-2-sulfanylideneimidazolidin-4-one

Smiles: CN1C(=O)C(CC2=CNC3=CC=CC=C32)NC1=S

InChiKey: TXUWMXQFNYDOEZ-UHFFFAOYSA-N

InChi: InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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