Rimeporide

Rimeporide is a potent and selective NHE1 inhibitor.

Product information

CAS Number: 187870-78-6

Molecular Weight: 333.38

Formula: C11H15N3O5S2

Synonym:

EMD-87580

Chemical Name: N-(diaminomethylidene)-2-methyl-4,5-bis(methylsulfonyl)benzamide

Smiles: CC1=CC(=C(C=C1C(=O)N=C(N)N)S(C)(=O)=O)S(C)(=O)=O

InChiKey: GROMEQPXDKRRIE-UHFFFAOYSA-N

InChi: InChI=1S/C11H15N3O5S2/c1-6-4-8(20(2,16)17)9(21(3,18)19)5-7(6)10(15)14-11(12)13/h4-5H,1-3H3,(H4,12,13,14,15)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 20 mg/mL (59.99 mM; Need ultrasonic and warming)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent.

References:

1. F.Porte-Thomé, et al. Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchenne muscular dystrophy. Neuromuscular Disorders. October 2015 Oct 25:259-260.

Products are for research use only. Not for human use.