Monensin sodium salt(Coban)

Monensin sodium salt is an antibiotic secreted by the bacteria Streptomyces cinnamonensis. Monensin sodium salt is an ionophore that mediates Na+/H+ exchange. Monensin sodium salt causes a marked enlargement of the MVBs and regulates exosome secretion.

Product information

CAS Number: 22373-78-0

Molecular Weight: 692.85

Formula: C36H61NaO11

Synonym:

Coban 45

Rumensin

NSC 343257

NSC343257

NSC-343257

Related CAS Number:

17090-79-8 (Monensin)

Chemical Name: sodium (2S, 3R, 4S)-4-[(2S, 5R, 7S, 8R, 9S)-2-[(2S, 2'R, 3'S, 5R, 5'R)-2-ethyl-5'-[(2S, 3S, 5R, 6R)-6-hydroxy-6-(hydroxymethyl)-3, 5-dimethyloxan-2-yl]-3'-methyl-[2, 2'-bioxolan]-5-yl]-9-hydroxy-2, 8-dimethyl-1, 6-dioxaspiro[4.5]decan-7-yl]-3-methoxy-2-methylpentanoate

Smiles: [Na+].C[C@]1(CC[C@@]2(C[C@@H](O)[C@H](C)[C@@H](O2)[C@@H](C)[C@@H](OC)[C@H](C)C([O-])=O)O1)[C@H]1CC[C@](CC)(O1)[C@H]1O[C@@H](C[C@H]1C)[C@@H]1O[C@](O)(CO)[C@@H](C)C[C@H]1C

InChiKey: XOIQMTLWECTKJL-WMQCWNTASA-M

InChi: InChI=1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23+,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,35+,36-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Ethanol 100 mg/mL (144.33 mM) DMSO 1.5 mg/mL (2.16 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Monensin sodium salt (Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+, Na+, K+, Rb+, Ag+, and TI+. Monensin A is able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and other biological activities. The antibacterial properties of monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes.

In Vivo:

LD50: Mice 335mg/kg (i.g.) ; Rats 36.5mg/kg (i.g.); Chickens 185mg/kg (i.g.).

References:

1. Huczynski A, et al. Bioorg Med Chem Lett, 2008, 18(8), 2585-2589.
2. Mollenhauer HH, et al. Biochim Biophys Acta, 1990, 1031(2), 225-246.
3. Pinkerton M, et al. J Mol Biol, 1970, 49(3), 533-546.

Products are for research use only. Not for human use.