Cryptotanshinone


Catalog No. Size PriceQuantity
M9696-2 Solid 2 mg $90
M9696-10 Solid 10 mg $270

Description

Cryptotanshinone is isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. The compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. It has been reported in the past that the compound counteracts inflammation through the inhibition of cyclooxygenase II activity and endothelin-1 expression.

Product information

CAS Number: 35825-57-1

Molecular Weight: 296.36

Formula: C19H20O3

Chemical Name: (1R)-1,6,6-trimethyl-1H,2H,6H,7H,8H,9H,10H,11H-phenanthro[1,2-b]furan-10,11-dione

Smiles: C[C@H]1COC2C3C=CC4=C(CCCC4(C)C)C=3C(=O)C(=O)C=21

InChiKey: GVKKJJOMQCNPGB-JTQLQIEISA-N

InChi: InChI=1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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