Description
UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 binds TNF with Kd of 13 nM. UCB-9260 also inhibits NF-κB with IC50 of 202 nM after TNF stimulation.
Product information
CAS Number: 1515888-53-5
Molecular Weight: 423.51
Formula: C26H25N5O
Chemical Name: (1-(2, 5-dimethylbenzyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-2-yl)(pyridin-4-yl)methanol
Smiles: CN1C=C(C=N1)C1=CC2=C(C=C1)N=C(C(O)C1C=CN=CC=1)N2CC1=CC(C)=CC=C1C
InChiKey: RZGFWGNCSYUEPR-UHFFFAOYSA-N
InChi: InChI=1S/C26H25N5O/c1-17-4-5-18(2)21(12-17)16-31-24-13-20(22-14-28-30(3)15-22)6-7-23(24)29-26(31)25(32)19-8-10-27-11-9-19/h4-15,25,32H,16H2,1-3H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 85 mg/mL(200.7 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- James O'Connell, et al. Nat Commun. 2019 Dec 19;10(1):5795.
Products are for research use only. Not for human use.
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