Cardamonin, a modulator of STAT3.

Cardamonin is a modulator of STAT3 activation in prostate cancer, repressing proliferation, invasion, and causing apoptosis. Cardamonin (Cardamomin), a natural flavone isolated from Alpinia katsumadai Hayata, acts as an aryl hydrocarbon receptor (AhR) activator. Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway .

Product information

CAS Number: 19309-14-9

Molecular Weight: 270.28

Formula: C16H14O4

Synonym:

Alpinetin chalcone

Cardamonin

Cardamomin

Chemical Name: (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one

Smiles: COC1=CC(O)=CC(O)=C1C(=O)/C=C/C1C=CC=CC=1

InChiKey: NYSZJNUIVUBQMM-BQYQJAHWSA-N

InChi: InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Solubility (25°C) DMSO: 54 mg/mL(199.79 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Cardamonin inhibits cancer cell growth by inducing G2/M phase cell cycle arrest and apoptosis via accumulation of ROS. Cardamonin has been reported to have anti-inflammatory and anti-tumor activities. Cardamonin inhibits activation of the NF-κB pathway, which in turn triggers ROS accumulation to activate JNK mitogen-activated protein kinase (MAPK). Cardamonin inhibits viability of NPC cells. It induces G2/M phase arrest in CNE-2 cells. Cardamonin-induced accumulation of ROS is mediated through inhibition of the NF-κB pathway. Cardamonin selectively blocks TRPA1 activation while did not interact with TRPV1 nor TRPV4 channel.

In Vivo:

Cardamonin inhibits tumor growth in vivo without serious side effects.

References:

1. Yuting Li, et al. Cell Death Dis. 2017, 8(8): e3024.
2. Wang S, et al. Molecules. 2016 Aug 29;21(9):pii: E1145.

Products are for research use only. Not for human use.