Tacalcitol (monohydrate) - CAS# 93129-94-3


Catalog No. Size PriceQuantity
M10786-2 Solid 2 mg $570
M10786-10 Solid 10 mg $2,280

Description

Tacalcitol monohydrate is is a D3 derivative, a VDR-like receptor promotes normal bone development by regulating calcium.

Product information

CAS Number: 93129-94-3

Molecular Weight: 434.65

Formula: C27H46O4

Synonym:

1, 24(R)-Dihydroxyvitamin D3, monohydrate

Chemical Name: (1R,3S,5Z)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R,5R)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol hydrate

Smiles: O.CC(C)[C@H](O)CC[C@@H](C)[C@H]1CC[C@H]2/C(/CCC[C@@]21C)=C/C=C1/C[C@@H](O)C[C@H](O)C/1=C

InChiKey: UCLYOJXQGOXQKJ-XXBHHXRKSA-N

InChi: InChI=1S/C27H44O3.H2O/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4;/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3;1H2/b20-9+,21-10-;/t18-,22-,23-,24+,25-,26+,27-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Koyano K, Saitoh Y, Oshida J, Takimoto-Kamimura M.Dimer and superstructure of the active form of a vitamin D3; 1 alpha,24(R)dihydroxy-vitamin D3 monohydrate, C27O3H44.H2O.Chem Pharm Bull (Tokyo). 2001 Mar;49(3):305-11.
  2. Fukuoka et alTacalcitol, an active vitamin D3, induces nerve growth factor in human epidermal keratinocytes. Skin Pharmacol.Appl.Skin Physiol. (2001) 14 226.
  3. Rostowska-Nadolska et al Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblasts. Adv.Med.Sci. (2010) 55 86.

Products are for research use only. Not for human use.

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