MAL-HA-OSu


Catalog No. size PriceQuantity
L60005 Inquiry $403
L60005-2 2mg solid $80
L60005-10 10mg solid $240

Description

EMCS crosslinker, also known as Mal-heptanoic NHS ester, is a non-cleavable, water insoluble, heterobifunctional protein crosslinking reagent that is commonly used to crosslink haptens to carrier proteins and enzymes to antibodies. EMCS crosslinking reagent's NHS ester and maleimide reactive groups react with amino and sulfhydryl moieties, respectively. The EMCS Crosslinker may be useful in the development of antibody drug conjugates (ADCs).

Product information

CAS Number: 55750-63-5

Molecular Weight: 308.29

Formula: C14H16N2O6

Synonym:

EMCS

EMCS Crosslinker

Mal-heptanoic NHS ester

N-[e-Maleimidocaproyloxy]succinimide ester

6-Maleimidohexanoic acid N-hydroxysuccinimide ester

Chemical Name: 2, 5-dioxopyrrolidin-1-yl 6-(2, 5-dioxo-2, 5-dihydro-1H-pyrrol-1-yl)hexanoate

Smiles: O=C(CCCCCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O

InChiKey: VLARLSIGSPVYHX-UHFFFAOYSA-N

InChi: InChI=1S/C14H16N2O6/c17-10-5-6-11(18)15(10)9-3-1-2-4-14(21)22-16-12(19)7-8-13(16)20/h5-6H,1-4,7-9H2

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 100 mg/mL (324.37 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

6-Maleimidohexanoic acid N-hydroxysuccinimide ester is coupled to the peptides, and then conjugated to the Adenovirus vector containing luciferase gene as adenovirus vector carrier.

References:

  1. Shinya Kida, et al. Studies on heterobifunctional cross-linking reagents, 6-maleimidohexanoic acid active esters. Chem Pharm Bull (Tokyo). 2007 Apr;55(4):685-7.
  2. Shinya Kida, et al. Evaluation of synthetic cell-penetrating peptides, Pro-rich peptide and octaargine derivatives, as adenovirus vector carrier. Protein Pept Lett. 2010 Feb;17(2):164-7.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed