Description
Product Information
| Storage: | Powder -20oC 3 years 4oC 2 years In solvent -80oC 6 months -20oC 1 month |
| Chemical Name: | 5-(3-chlorophenyl)-N-(4-(morpholinomethyl)phenyl)furan-2-carboxamide |
| Solubility: | 10 mM in DMSO |
| Purity: | >98% |
| CAS#: | 638156-11-3 |
| Formula: | C22H21CIN2O3 |
| Molecular Weight: | 396.87 |
Biological Activity:
CID-2011756 is a cell-active ATP competitive and specific PKD1 inhibitor that inhibits phorbol ester-induced endogenous PKD1 activation in LNCaP prostate cancer cells. IC50 Value: 10±0.7 uM (cellular inhibition of phospho-Ser916-PKD1 activity) [1] Target: PKD CID 2011756, has pan-PKD inhibitory effects (PKD2 IC50 = 0.6±0.1 uM; PKD3 IC50 = 0.7±0.2 uM) with similar, albeit not identical, potencies which may be expected for an ATP competitive inhibitor. CID 2011756 was the most potent of the inhibitors with a cellular EC50 of 10±0.7 uM (n = 3), an EC50 value comparable to that of our previously described benzoxoloazepinolone.
Reference:
[1]. Sharlow ER, et al. Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. PLoS One. 2011;6(10):e25134.
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