AG 18


Catalog No. Size PriceQuantity
M11312-2 Solid 2 mg $85
M11312-10 Solid 10 mg $255

Description

AG-18, also known as RG-50810; RG-50858; TX 825; Tyrphostin A23; Tyrphostin AG-18. AG-18 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 35 µM in the human epidermoid carcinoma cell line A431. AG-18 inhibits internalization of the transferrin receptor by perturbing the interaction between tyrosine motifs and the medium chain subunit of the AP-2 adaptor complex.

Product information

CAS Number: 118409-57-7

Molecular Weight: 186.17

Formula: C10H6N2O2

Chemical Name: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile

Smiles: N#CC(=CC1=CC(O)=C(O)C=C1)C#N

InChiKey: VTJXFTPMFYAJJU-UHFFFAOYSA-N

InChi: InChI=1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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