Bis-choline tetrathiomolybdate is a cytosolic superoxide dismutase (SOD1) inhibitor potentially for the treatment of Wilson's disease.
CAS Number: 649749-10-0
Molecular Weight: 434.56
Chemical Name: bis((2-hydroxyethyl)trimethylazanium) disulfanylidenemolybdenum disulfanide
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in water
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
ATN-224 induced peroxynitrite-dependent cell death, independent of Bcl-2 status, at nanomolar concentrations in cell culture models of T cell lymphoid malignancies. To determine the ability of ATN-224 to induce cell death in primary patient samples, ATN-224 was tested in pre-treatment, precursor B cell acute lymphoblastic leukemia (B-ALL), which commonly overexpresses Bcl-2. Five B-ALL samples were treated with 12.5 nM and 25 nM concentrations of ATN-224 for 24 h. A decrease in the number of viable cells in all five B-ALL samples was observed (Figure 7). There appears to be a concentration dependent decrease occurring in most of the samples, with responses ranging from 11–51% at 12.5 nM and 14–46% at 25 nM. These results imply that ATN-224 has therapeutic potential in the treatment of B cell lymphoid malignancies, and may be particularly useful in those malignancies which overexpress Bcl-2.
- Lee K, Briehl MM, Mazar AP, Batinic-Haberle I, Reboucas JS, Glinsmann-Gibson B, Rimsza LM, Tome ME. The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies. Free Radic Biol Med. 2013 Jul;60:157-67. doi: 10.1016/j.freeradbiomed.2013.02.003. Epub 2013 Feb 14. PMID: 23416365; PMCID: PMC3654089. 2. Lee K, Hart MR, Briehl MM, Mazar AP, Tome ME. The copper chelator ATN-224 induces caspase-independent cell death in diffuse large B cell lymphoma. Int J Oncol. 2014 Jul;45(1):439-47.
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