AZD-4635, also known as HTL-1071, is an orally available, small molecule adenosine A2A receptor antagonist.
CAS Number: 1321514-06-0
Molecular Weight: 315.73
Chemical Name: 6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1, 2, 4-triazin-3-amine
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 83.3 mg/mL (263.83 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In CHO cells stably expressing human A2AR, the IC50s of AZD4635 for inhibition of cAMP production are 0.79, 10.0 and 142.9 nM in the presense of 0.1, 1 and 10 μM adenosine, respectively.
Blockade of A2AR signaling with AZD4635 could reduce tumor burden and enhance antitumor immunity.
- Alexandra Borodovsky, et al. Abstract 5580: Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5580.
Products are for research use only. Not for human use.
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