Catalog No. Size PriceQuantity
M11414-2 2mg solid $105
M11414-10 10mg solid $315


YKL-05-099 is a selective inhibitor of Salt-Inducible Kinase (SIK).

Product information

CAS Number: 1936529-65-5

Molecular Weight: 600.11

Formula: C32H34ClN7O3

Chemical Name: 3-(2-Chloro-6-methylphenyl)-7-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-1-(5-methoxypyridin-2-yl)-3, 4-dihydropyrimido[4, 5-d]pyrimidin-2(1H)-one

Smiles: CN1CCC(CC1)C1=CC(OC)=C(C=C1)NC1=NC2=C(CN(C(=O)N2C2=CC=C(C=N2)OC)C2=C(Cl)C=CC=C2C)C=N1


InChi: InChI=1S/C32H34ClN7O3/c1-20-6-5-7-25(33)29(20)39-19-23-17-35-31(37-30(23)40(32(39)41)28-11-9-24(42-3)18-34-28)36-26-10-8-22(16-27(26)43-4)21-12-14-38(2)15-13-21/h5-11,16-18,21H,12-15,19H2,1-4H3,(H,35,36,37)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 100 mg/mL(166.63 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

YKL-05-099 displays cell-based activities consistent with SIK inhibition. Pre-treatment with the indicated concentrations of YKL-05-099 for 24 hr potentiates IL-10 production by Zymosan A-stimulated BMDCs.

In Vivo:

Well-tolerated doses of YKL-05-099 achieve free serum concentrations above its IC50 for SIK2 inhibition for > 16 hours and reduce phosphorylation of a known SIK substrate in vivo. While in vivo active doses of YKL-05-099 recapitulate the effects of SIK inhibition on inflammatory cytokine responses, they do not induce metabolic abnormalities observed in Sik2 knockout mice. These results identify YKL-05-099 as a useful probe to investigate SIK function in vivo, and further support the development of SIK inhibitors for treatment of inflammatory disorders.


  1. Thomas B Sundberg, et al. ACS Chem Biol. 2016 Aug 19;11(8):2105-11.

Products are for research use only. Not for human use.

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