Eprodisate, also known as 3-PDS; NC-503; 3PDS, is an orally available disodium salt form of eprodisate, a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis. Upon administration, eprodisate competitively binds to the glycosaminoglycan binding sites on serum amyloid A (SAA), which inhibits the formation of the glycosaminoglycan-amyloid fibril aggregate. This prevents the formation of amyloid deposits in certain organs, especially the kidneys, in AA amyloidosis.
CAS Number: 36589-58-9
Molecular Weight: 248.19
Chemical Name: 1, 3-Propanedisulfonic acid, disodium salt
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Water: 49 mg/mL(197.42 mM)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
- Clinicaltrials gov. Efficacy and Safety Study of KIACTA in Preventing Renal Function Decline in AA Amyloidosis. May 15, 2015. Retrieved 12 June 2015.
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