CPDA inhibitor


Catalog No. Size PriceQuantity
M11444-2 2mg solid $105
M11444-10 10mg solid $315

Description

CPDA is a novel potent SH2 domain-containing inositol phosphatase 2 (SHIP2) inhibitor.

Product information

CAS Number: 1415834-63-7

Molecular Weight: 388.80

Formula: C20H15ClF2N2O2

Chemical Name: N-(4-((4-chlorobenzyl)oxy)pyridin-2-yl)-2-(2, 6-difluorophenyl)acetamide

Smiles: O=C(CC1C(F)=CC=CC=1F)NC1=CC(=CC=N1)OCC1C=CC(Cl)=CC=1

InChiKey: GISJHCLTIVIGLX-UHFFFAOYSA-N

InChi: InChI=1S/C20H15ClF2N2O2/c21-14-6-4-13(5-7-14)12-27-15-8-9-24-19(10-15)25-20(26)11-16-17(22)2-1-3-18(16)23/h1-10H,11-12H2,(H,24,25,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 50 mg/mL (128.60 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CPDA enhances insulin signaling.

In Vivo:

CPDA greatly improves abnormal glucose metabolism in diabetic animals. CPDA improves the abnormal glucose metabolism in db/db mice.

References:

  1. Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2). Eur J Med Chem. 2013 Apr;62:649-660.

Products are for research use only. Not for human use.

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