JUN76288


Catalog No. Size PriceQuantity
M11450-2 2mg solid $125
M11450-10 10mg solid $375

Description

JUN76288, also known WEE1-IN-3, is a potent WEE1 kinase inhibitors useful in treatment of cancer and other proliferative diseases.

Product information

CAS Number: 2272976-28-8

Molecular Weight: 497.59

Formula: C28H31N7O2

Synonym:

WEE1-IN-3

Chemical Name: 6-[(2', 3'-Dihydro-2'-methylspiro[cyclopropane-1, 4'(1'H)-isoquinolin]-7'-yl)amino]-1, 2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-2-(2-propen-1-yl)-3H-pyrazolo[3, 4-d]pyrimidin-3-one

Smiles: CC(C)(O)C1=CC=CC(=N1)N1C2=NC(NC3=CC4CN(C)CC5(CC5)C=4C=C3)=NC=C2C(=O)N1CC=C

InChiKey: JSZFIXAMFNNRKS-UHFFFAOYSA-N

InChi: InChI=1S/C28H31N7O2/c1-5-13-34-25(36)20-15-29-26(32-24(20)35(34)23-8-6-7-22(31-23)27(2,3)37)30-19-9-10-21-18(14-19)16-33(4)17-28(21)11-12-28/h5-10,14-15,37H,1,11-13,16-17H2,2-4H3,(H,29,30,32)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

JUN76288 inhibits cancer cell growth with IC50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively. JUN76288 is overexpressed in various cancer types, JUN76288 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ΌΝΑ repair before mitotic entry. Normal cells repair damaged DNA during GI arrest. Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair.

References:

  1. Peter Qinhua HUANG, et al. 1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs. WO2019028008A1.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed