NS 3728


Catalog No. Size PriceQuantity
M11479-2 2mg solid $80
M11479-10 10mg solid $240

Description

NS 3728 is ANO1 inhibitor.

Product information

CAS Number: 265646-85-3

Molecular Weight: 495.18

Formula: C16H9BrF6N6O

Synonym:

NS-3728

NS 3728

Endovion

SCO‐101

SCO 101

Chemical Name: 1-[3, 5-bis(trifluoromethyl)phenyl]-3-[4-bromo-2-(1H-1, 2, 3, 4-tetrazol-5-yl)phenyl]urea

Smiles: O=C(NC1=CC=C(Br)C=C1C1NN=NN=1)NC1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F

InChiKey: AEFYFGMSRKDXHZ-UHFFFAOYSA-N

InChi: InChI=1S/C16H9BrF6N6O/c17-9-1-2-12(11(6-9)13-26-28-29-27-13)25-14(30)24-10-4-7(15(18,19)20)3-8(5-10)16(21,22)23/h1-6H,(H2,24,25,30)(H,26,27,28,29)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (252.43 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Sauter DR, et al. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 2015 Jul;467(7):1495-1508.
  2. Sørensen BH, et al. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against CDDP-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C857-73.

Products are for research use only. Not for human use.

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