ARN 14494

Catalog No. Size PriceQuantity
M11480-2 2mg solid $125
M11480-10 10mg solid $375


ARN 14494 is a potent serine palmitoyltransferase inhibitor (IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.

Product information

CAS Number: 1037837-27-6

Molecular Weight: 424.54

Formula: C24H32N4O3

Chemical Name: 1-(1-(2-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-2-oxoethyl)piperidin-4-yl)-N-methyl-2-oxoindoline-5-carboxamide

Smiles: CNC(=O)C1=CC2CC(=O)N(C3CCN(CC(=O)N4CC5CCCC5C4)CC3)C=2C=C1


InChi: InChI=1S/C24H32N4O3/c1-25-24(31)16-5-6-21-19(11-16)12-22(29)28(21)20-7-9-26(10-8-20)15-23(30)27-13-17-3-2-4-18(17)14-27/h5-6,11,17-18,20H,2-4,7-10,12-15H2,1H3,(H,25,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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