Galidesivir dihydrochloride


Catalog No. Size PriceQuantity
M11482-2 Contact sales@xcessbio.com for quotation $100
M11482-10 Contact sales@xcessbio.com for quotation $100

Description

Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide. In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (EC50 values range from 3 μM to >100 μM). Galidesivir protects against Ebola and Marburg viral infection in animal models.

Product information

CAS Number: 1373208-51-5

Molecular Weight: 338.19

Formula: C11H17Cl2N5O3

Chemical Name: (2S, 3S, 4R, 5R)-2-(4-Amino-5H-pyrrolo[3, 2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3, 4-pyrrolidinediol dihydrochloride

Smiles: Cl.Cl.NC1=NC=NC2C(=CNC=21)[C@@H]1N[C@H](CO)[C@@H](O)[C@H]1O

InChiKey: LOHGEHBUEDUIRK-PUSSMWDMSA-N

InChi: InChI=1S/C11H15N5O3.2ClH/c12-11-8-6(14-3-15-11)4(1-13-8)7-10(19)9(18)5(2-17)16-7;;/h1,3,5,7,9-10,13,16-19H,2H2,(H2,12,14,15);2*1H/t5-,7+,9-,10+;;/m1../s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Warren et al (2014) Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 508 402 PMID: 24590073
  2. Li & De Clercq (2020) Therapeutic options for the 2019 novel coronavirus (2019-nCoV). Nat.Rev.Drug Discov. 19 149 PMID: 32127666

Products are for research use only. Not for human use.

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