KT 182

Catalog No. Size PriceQuantity
M11484-2 2mg solid $160
M11484-10 10mg solid $510


KT 182 is a potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 1.7 nM). KT 182 exhibits selectively for ABHD6 over other brain and liver serine hydrolases, but does exhibit some activity at carboxylesterase-1. KT 182 inhibits ABHD6 activity in the brain and liver in mice following intraperitoneal administration.

Product information

CAS Number: 1402612-62-7

Molecular Weight: 438.52

Formula: C27H26N4O2

Chemical Name: [4-[3'-(Hydroxymethyl)[1, 1'-biphenyl]-4-yl]-1H-1, 2, 3-triazol-1-yl](2-phenyl-1-piperidinyl)methanone

Smiles: OCC1=CC(=CC=C1)C1C=CC(=CC=1)C1=CN(N=N1)C(=O)N1CCCCC1C1C=CC=CC=1


InChi: InChI=1S/C27H26N4O2/c32-19-20-7-6-10-24(17-20)21-12-14-22(15-13-21)25-18-31(29-28-25)27(33)30-16-5-4-11-26(30)23-8-2-1-3-9-23/h1-3,6-10,12-15,17-18,26,32H,4-5,11,16,19H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (228.04 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Hsu KL, et al. Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6). J Med Chem. 2013 Nov 14;56(21):8270-9.

Products are for research use only. Not for human use.

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